CortAlign contains a unique variety of botanicals and nutrients shown to have a synergistic blunting effect on stress and anxiety, as well as normalizing cortisol secretion. Ashwagandha has a number of adaptogenic effects, including modulating GABA receptors, which is partly responsible for the significant reduction in anxiety and stress as shown in clinical trials. The KSM-66 formulation of ashwagandha specifically has been shown to reduce serum cortisol levels by 27%, and improve markers of depression, stress, and anxiety compared to placebo.
The combination of magnolia and phellodendron (Relora® blend) has a synergistic effect for reducing stress and anxiety, and has been shown to reduce salivary cortisol levels and perception of stress, to improve other mood parameters such as depression, and to prevent stress-related weight gain compared to placebo. L-theanine (Suntheanine®) has also been shown to reduce anxiety in clinical trials, and to reduce both subjective stress and cortisol production in response to a stressful event. Phosphatidylserine plays a critical role in neuronal cell structure and function, and has been shown to blunt the stress response, improve mood, and normalize cortisol release.